Lifestyle

Connective tissue protein fights bacterial infection

A connective tissue protein known to support the framework of organs also encourages immune responses that fight bacterial infections, while restraining responses that can be deadly in the condition called sepsis, a new study finds. Led by researchers from NYU Grossman School of Medicine, the work revolves around the extracellular matrix (ECM) of connective tissues, […]

Lifestyle

Alzheimer’s and aducanumab: Unjust profits and false hopes

The U.S. Food and Drug Administration’s controversial decision to approve aducanumab for the treatment of Alzheimer’s disease raises at least three major ethical issues that need to be addressed, states a new article in the Hastings Center Report: Billions of dollars in Medicare resources (which is to say, taxpayer dollars) are at risk of being […]

Lifestyle

Pediatricians ID cause of muscle breakdown in rare disease found on newborn screening

It was a nagging mystery: A rare-disease expert at UPMC Children’s Hospital of Pittsburgh had found a successful treatment for two of the deadliest symptoms of one of the more common classes of rare diseases diagnosed by newborn screenings, but one symptom—painful episodes of muscle breakdown that land victims in intensive care—persisted. Today, the scientists […]

Lifestyle

Researchers discover protein complex that promotes cancer growth

A discovery by a team of researchers, led by a Geisinger professor, could yield a potential new treatment for breast cancer. In a study published this month in Cell Reports, the team used small molecules known as peptides to disrupt a complex of two proteins, RBM39 and MLL1, that is found in breast cancer cells […]

Lifestyle

Mouse brain imaged from the microscopic to the macroscopic level

Researchers at the University of Chicago and the U.S. Department of Energy’s (DOE) Argonne National Laboratory have leveraged existing advanced X-ray microscopy techniques to bridge the gap between MRI (magnetic resonance imaging) and electron microscopy imaging, providing a viable pipeline for multiscale whole brain imaging within the same brain. The proof-of-concept demonstration involved imaging an […]

Lifestyle

Researchers discover unique immune response by cells critical to lung health

Researchers at Children’s Hospital of Philadelphia (CHOP) have discovered that a specific type of lung cell exhibits unconventional immune properties and may contribute to the outcome of respiratory viral infections. The researchers focused on type II alveolar (AT2) cells, which are non-immune cells of the lung that are critical for basic lung health and tissue […]

Lifestyle

Unique neuron can guide our way home by turning compasses into a gyroscope

Finding our way home from work or school is something most of us take for granted. Persons with Alzheimer’s disease, however, can get lost even when moving between such familiar locations and often struggle to find their way home. Exactly the same inability to get home is also seen in people who do not have […]